General details

In recent years, pan-tumor NTRK gene fusions have emerged as targets for cancer therapy. This is an open call for FFPE tissue blocks to help us (CPQA-AQCP) build a small tissue microarray for the purpose of NTRK IHC proficiency testing as well as providing NTRK IHC validation assistance.
• Our focus is on curating secretory breast carcinoma and/or salivary MASC blocks. We have selected these tissue types because of the higher incidence of NTRK Fusions in these tumors. Confirmation of a NTRK gene fusion in the block is not required by the donor lab for submission to this project.
• We will be most happy to receive FFPE from other tumour types with a confirmed NTRK fusion.
• FFPE block(s) and an accompanying H&E slide from each block is required. Four 0.6mm cores will be taken from the block and the block returned on request

Why join the collaboration:

• Work with a renowned global EQA/PT provider to support NTRK IHC proficiency testing
• Be eligible to free participation in the CPQA pan-TRK EQA program should your lab already offer an NTRK IHC service
• Receive access to TMA slides and assistance for labs who wish to develop and validate Pan-TRK IHC
Please note: This collaboration is open until March 26th but may close once 20 labs have registered interest and been enrolled.

Requirements

To be eligible to participate in this collaboration please ensure that:
1. Your lab will be able to share one FFPE block and an accompanying H&E slide with confirmed or unconfirmed TRK fusions
• CPQA address details will be shared on enrollment onto the DXRX collaboration zone
2. Lab assay details reflect
• Current NTRK testing methods and turnaround times
• Q1, Q2, Q3 2020 NTRK volumes for indications covered within your service
*Please note, where multiple assays are available in-house, these must be logged as individual assays per technology

Documentation

Download