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Association for Molecular Pathology AMP 2021 Poster #ST61

Fri Aug 26 2022

In this poster we assessed the US solid tumor testing landscape utilizing our Diagnostic Network for Precision Medicine (DXRX) data platform. Real-world data from 52,037 patients between Q3 2017 to Q3 2020 was used to calculate MSI and MMR testing rates across the following metastatic tumor indications: Non-Small Cell Lung Cancer (NSCLC), bladder cancer, cervical cancer, Colorectal Cancer (CRC), Triple-Negative Breast Cancer (TNBC) and Gastrointestinal Stromal Tumor (GIST).

Association for Molecular Pathology AMP 2021 Poster #ST61

Association for Molecular Pathology AMP 2021 Poster #ST61

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AMP Poster #ST61 Overview:

MSI and MMR are well established diagnostic risk biomarkers for Lynch Syndrome (LS). Predictive clinical utility of MSI/MMR status is evolving, with 2 therapy approvals identifying pan-tumor and endometrial cancer patients eligible for Immune Checkpoint Inhibitors (ICI).

Today, MSI/MMR testing for solid tumors is recommended to evaluate for LS and to predict therapy response. Sufficient adoption of MSI/MMR testing depends on physician awareness of clinical utility, test availability and adequate reimbursement. Either Microsatellite Instability-High (MSI-H) or a Deficient DNA Mismatch Repair (dMMR) result is required to prescribe therapy. This could lead to confusion and disparity between MSI and MMR testing.

We assessed the US solid tumor testing landscape utilizing our Diagnostic Network for Precision Medicine (DXRX) data platform. Real-world data from 52,037 patients between Q3 2017 to Q3 2020 was used to calculate MSI and MMR testing rates across the following metastatic tumor indications: Non-Small Cell Lung Cancer (NSCLC), bladder cancer, cervical cancer, Colorectal Cancer (CRC), Triple-Negative Breast Cancer (TNBC) and Gastrointestinal Stromal Tumor (GIST). One hundred and fifty-nine labs were also profiled to assess in-house MSI and MMR testing capabilities and methodology.

Association for Molecular Pathology AMP 2021 Poster #ST61

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